Burkitt lymphoma research proposal in kenya

Thomas Hi Peace, Hawina — shetahtahtahtah ketibl koloka tedengitseni aleka:

Burkitt lymphoma research proposal in kenya

The workshop featured 15 plenary talks by delegates representing 13 institutions that either fund or implement research on BL targeting AORTIC delegates primarily interested in pediatric oncology.

The Burkitt lymphoma research proposal in kenya outcomes of the meeting were improved sharing of knowledge and experience about ongoing epidemiologic BL research, BL treatment in different settings, the role of cancer registries in cancer research, and opportunities for African scientists to publish in scientific journals.

The idea of forming a consortium of BL to improve coordination, information sharing, accelerate discovery, dissemination, and translation of knowledge and to build capacity, while reducing redundant efforts was discussed. Here, we summarize the presentations and discussions from the workshop. Table S1 [ 1 ].

The workshop objectives were to highlight Burkitt Lymphoma BL research in East Africa, one of the regions with the highest recorded rates of BL, and highlight the seminal contribution of BL research to cancer research in general and in Africa in particular. The workshop aimed to increase awareness about ongoing funded BL research, including epidemiology, treatment, and immunology; and to highlight the importance of cancer registration, capacity-building, and scientific publication in BL research in East Africa.

The workshop also provided a platform to discuss ways to improve collaboration. Here we summarize the presentations, discussions, and conclusions from the workshop. Since BL is the most common childhood cancer, and Pf malaria, the putative cause, is the leading cause of morbidity and mortality in East Africa, findings from EMBLEM could influence the scope and direction of cancer research, care, prevention in East Africa.

Historically, BL research in Africa has influenced oncology practice [ 2 ], including the first effective use of chemotherapy for BL, first demonstrated in the East Africa [ 3 ], and then used elsewhere and for other types of cancer [ 4 ].

Those early studies showed the value of combination therapy and CNS prophylaxis [ 5 ]. The uneven geographical patterns of BL, notably high incidence in low-lying humid areas in Africa suggested infectious etiology [ 6 ] and led to the discovery in of Epstein-Barr virus EBV [ 7 ] as the first human virus associated with a human cancer [ 8 ].

EBV cooperates with co-factors, particularly Pf malaria [ 10 ], which was implicated based on correlational studies of the geographical distribution of Pf malaria with that of BL. Recent studies using anti-malaria antibody assays are providing strong evidence for a role of malaria in BL [ 11 ].

The results from these studies are difficult to interpret because antibody levels may change after disease onset i. To overcome this limitation, some investigators have measured genetic polymorphisms in the hemoglobin gene that confer resistance to severe fatal forms of malaria among heterozygotes [ 12 ] to investigate the link between malaria and BL.

Genetic polymorphisms are ideal because they are not subject to reverse causality bias and their distribution is governed by Mendelian randomization in the population [ 13 ].

In the study conducted in Nigeria, the frequency of the sickle cell trait in 95 BL cases was half that found in age- and sex-matched hospital controls [ 14 ].

Burkitt lymphoma research proposal in kenya

However, these results were not replicated in the other two studies conducted in Uganda 36 cases and controls [ 15 ] or in Ghana cases and controls [ 16 ] or in a recent study that was conducted in Kenya looking at cases and ethnically matched controls [ 18 ]. Thus, further studies are needed to evaluate effects of multiple genes simultaneously and also take into account epistatic positive and negative relationships between genes [ 19 ] to obtain valid results.

Burkitt lymphoma research proposal in kenya

The study will compare the cases and controls for 44 polymorphisms in 25 genes that are associated with Pf malaria resistance [ 21 ]. In secondary analyses, association of being a case with tag SNPs in the 25 genes will be evaluated to identify associations with non-candidate SNPs SNPs with no association with malaria disease.

Mbulaiteye noted replication of EMBLEM findings is needed and called for other studies to be conducted in similar settings, particularly in West Africa. He emphasized the importance of standardization of protocols through collaboration to accelerate the pace of discovery, replication, and translation, with the ultimate objective being to improve care and prevent BL.A one-day workshop on Burkitt lymphoma (BL) was held at the 9(th) African Organization for Research and Training in Cancer (AORTIC) conference in in Durban, South Africa.

Burkitt lymphoma (BL) is a unique B-cell lymphoma characterized by a high proliferation rate and cytogenetic changes related to c-myc proto-oncogene overexpression.

Burkitt lymphoma is a highly aggressive B-cell lymphoma that is most frequently seen in children and young adults in endemic areas.

Burkitt lymphoma (BL) is a unique B-cell lymphoma characterized by a high proliferation rate and cytogenetic changes related to c-myc proto-oncogene overexpression. Burkitt lymphoma is a highly aggressive B-cell lymphoma that is most frequently seen in children and young adults in endemic areas. Burkitt Lymphoma Research Proposal in Kenya. Burkitt Lymphoma (BL) is among the most aggressive cancerous tumors that attack humans. It is named after David Burkitt who first discovered and described this kind of tumor in children in Africa. A one-day workshop on Burkitt lymphoma (BL) was held at the 9(th) African Organization for Research and Training in Cancer (AORTIC) conference in in Durban, South Africa.

Burkitt lymphoma research in East Africa: highlights from the 9th African organization for research and training in cancer conference held in Durban, South Africa in J Natl Cancer Inst , 42(1)– Organization for Research and Training in Cancer in Durban South Africa.

Burkitt Lymphoma Research Essay. Running Head: Burkitt Lymphoma Research Proposal in Kenya. Name of the Author University Affiliation Course Date of Submission Burkitt Lymphoma Research Proposal in Kenya.

Burkitt Lymphoma (BL) is among the . Abstract. A one-day workshop on Burkitt lymphoma (BL) was held at the 9 th African Organization for Research and Training in Cancer (AORTIC) conference in in Durban, South Africa. The workshop featured 15 plenary talks by delegates representing 13 institutions that either fund or implement research on BL targeting AORTIC delegates primarily interested in pediatric oncology.

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Burkitt Lymphoma Research Proposal in Kenya. Burkitt Lymphoma (BL) is among the most aggressive cancerous tumors that attack humans. It is named after David Burkitt who first discovered and described this kind of tumor in children in Africa.

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